2'-岩藻糖基乳糖 (2'-FL)

2'- 岩藻糖基乳糖 (2'-FL) 是母乳中最丰富的HMO。


 

健康益处

研究表明,2'-FL 具有一定的功能益处 , 包括有利于肠道完整性1和有益菌的生长2,以及对认知和记忆的益处3。  此外,它还有助于正向免疫反应4。 科学研究还证实,它支持早产儿正常免疫系统和消化系统的发育5。  


关于 2'-FL HMO的研究

母乳中的 2'-岩藻糖基乳糖(2'-FL)浓度非常高,因此在早期的科学研究中发现,这种特定的低聚糖可以减少潜在的肠道有害菌6, 并缓解诸如偶尔的稀便7和呼吸不适等问题8

 

参考文献

1 Natividad, J. M., Rytz, A., Keddani, S., Bergonzelli, G., & Garcia-Rodenas, C. L. (2020)。 Blends of Human Milk Oligosaccharides Confer Intestinal Epithelial Barrier Protection In Vitro. Nutrients, 12(10), 3047.
2 Gotho et al., 2018, Kostopoulus et al., 2020.
3 Berger, Paige K., et al. "Human milk oligosaccharide 2’-fucosyllactose links feedings at 1 month to cognitive development at 24 months in infants of normal and overweight mothers." PloS one 15.2 (2020):e0228323。
4 Goehring, Karen C., et al. "Similar to those who are breastfed, infants fed a formula containing 2′-fucosyllactose have lower inflammatory cytokines in a randomized controlled trial." The Journal of nutrition 146.12. (2016): 2559-2566.
5 Good, Misty, et al. "The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotizing enterocolitis by enhancing mesenteric perfusion in the neonatal intestine." British journal of nutrition 116.7 (2016): 1175-1187.
6 Weichert, Stefan, et al. "Bioengineered 2′-fucosyllactose and 3-fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory cell lines." Nutrition research 33.10 (2013): 831-838.
7 Palsson, Olafur S., et al. "Human Milk Oligosaccharides Support Normal Bowel Function and Improve Symptoms of Irritable Bowel Syndrome: A Multicenter, Open-Label Trial." Clinical and Translational Gastroenterology 11.12 (2020).
8 Puccio, Giuseppe, et al. "Effects of infant formula with human milk oligosaccharides on growth and morbidity: a randomized multicenter trial." Journal of pediatric gastroenterology and nutrition 64.4 (2017): 624.

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