2'-FL is the most abundant HMO in breast milk and is most researched together with LNT, 3-FL, 6’-SL and 3’-SL. Our team has successfully established the industrial production of the five most important human milk oligosaccharides (HMOs) and thus launched its next product generation, the 5HMO-Mix, which contains both neutral and acidic HMOs.
Health benefits and studies
All HMOs in the 5HMO-Mix have been reported to reduce growth of several common harmful bacteria. The single ingredients of the new HMO-Mix support a natural gut microbiome by nourishing beneficial gut bacteria such as bifidobacteria, lactobacilli and bacteroides.1, 2 Furthermore, 2′-FL, 3-FL and 6′-SL support intestinal motility and intestinal epithelial cell maturation.3, 4 Fucosylated and sialylated HMOs also exert immune benefits. They may help support normal levels of cytokines and immune markers in infants5 and balance immune responses.6 Specifically 3′-SL and 6′-SL are suggested to positively support brain development in infants by affecting cognition and regulation of neurons.7
1 Yu Z et al. Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes. Glycobiology 2013; 23: 1281-1292.
2 Thongaram T et al. Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli. J Dairy Sci. 2017; 100: 7825-7833.
3 Bienenstock J et al. Fucosylated but not sialylated milk oligosaccharides diminish colon motor contractions. PLoS ONE 2013, 8: e76236.
4 Holscher et al. Human Milk Oligosaccharides Influence Intestinal Epithelial Cell Maturation In Vitro. J Pediatr Gastroenterol Nutr. 2017; 64(2):296-301.
5 Göhring et al., 2016.
6 Xiao et al. Human milk oligosaccharides promote immune tolerance via direct interactions with human dendritic cells. Eur J Immunol. 2019, 49(7):1001-1014.
7 Wang B et al. Dietary sialic acid supplementation improves learning and memory in piglets. Am J Clin Nutr. 2007;85(2):561-9.