One of the world's largest clinical studies on probiotics reinforces significant gastrointestinal benefits of the probiotic strain named BB-12®

One of the world's largest clinical studies on probiotics reinforces significant gastrointestinal benefits of the probiotic strain named BB-12®
Press Release | Sep 25. 2015 10:39 GMT

Millions of people around the world suffer from a range of gastrointestinal symptoms. Worldwide, 12% of the population suffers from constipation[1]. In some regions, the prevalence of irritable bowel syndrome is as high as 23%.[2] One widely cited study concludes that normal bowel function is enjoyed by less than half of the population[3].

Results from one of the world’s largest clinical studies on probiotics now show that the probiotic strain named BB-12® can be part of the solution by improving bowel regularity.

The study, recently published in British Journal of Nutrition,was initiated by Chr. Hansen in 2011. It included more than 1200 subjects in France, UK and Germany; all healthy but experiencing low defecation frequency and abdominal discomfort. The study has produced the largest dataset ever published from a randomized, placebo-controlled study on the effect of probiotics on bowel function.

Results from the study show that the odds for having more regular bowel movements were significantly higher when consuming the BB-12® probiotic strain for four weeks, compared to the placebo group. This verifies results from previous studies, and shows a clinically relevant effect of the probiotic strain on bowel regularity.

Mikkel Jungersen, Scientific Advisor, Human Health & Nutrition, Chr. Hansen, says: “Once again, it is confirmed that the BB-12® probiotic strain can bring significant gastrointestinal benefits to those who experience digestive issues. What is truly unique about this study is its size, of more than 1200 subjects varying in age from 18 to 70, which has resulted in the largest dataset available on the effect of probiotics on bowel function”.

The best documented Bifidobacterium in the world

The BB-12® probiotic strain originates from Chr. Hansen’s culture collection, and has been used as an ingredient in food and dietary supplements since 1985. Over the last 30 years, more than 170 clinical studies have shown that this probiotic strain has a positive effect on the immune and gastrointestinal system. Today, it is consumed by hundreds of millions of people all over the world every day.

Mikkel Jungersen continues: “We are committed to delivering the best documented probiotics and the BB-12® probiotic strain is the best documented Bifidobacterium in the world. With these new results, it now truly stands out as a strong probiotics within bowel function.”

For more information on the study or on the probiotic strain named BB-12®,please do not hesitate to contact Mikkel Jungersen, Dkmkj@chr-hansen.com or visit the product website.



The Study

  • Eskesen et al. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12® on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomized, double-blind, placebo-controlled, parallel-group trial.

E-published ahead of print online September 21, 2015 in British Journal of Nutrition.

[1] A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation. Alimentary Pharmacology & Therapeutics; 2008.

[2] International Foundations for Functional Gastrointestinal Disorders (IFFGD), April 2014

[3] Hughes et al.: Defecation frequency and timing, and stool form in the general population: a prospective study. Gut 1992: 33, pp. 818-824


Chr. Hansen es una empresa global líder de biociencia que desarrolla soluciones naturales para las industrias de alimentación y nutrición, farmacéutica y agrícola. Desarrollamos y producimos cultivos, enzimas, probióticos y colorantes naturales para una gran diversidad de alimentos, dulces, bebidas, suplementos dietéticos, piensos para animales y fitosanitarios. Nuestra innovación en productos se desarrolla sobre la base de unas 40.000 cepas microbianas, a las que solemos llamar «bacterias beneficiosas». Nuestras soluciones permiten que los fabricantes de alimentos produzcan más con menos, al tiempo que también disminuyen el uso de productos químicos y aditivos sintéticos, lo que hace que nuestros productos sean muy apropiados en el mundo actual. La sostenibilidad forma parte integrante de la visión de Chr. Hansen de mejorar los alimentos y la salud. En 2019 Chr. Hansen fue clasificada como la compañía más sostenible del mundo por Corporate Knights, gracias a nuestros grandes esfuerzos en pro de la sostenibilidad y a las numerosas relaciones de colaboración con nuestros clientes. Desde hace más de 145 años aportamos valor a nuestros socios comerciales y, en última instancia, a los consumidores finales de todo el mundo. Nos llena de orgullo que cada día más de mil millones de personas consuman productos que contienen nuestros ingredientes naturales. Chr. Hansen fue fundada en 1874 y cotiza en la bolsa Nasdaq de Copenhague.

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