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Lactobacillus rhamnosus, LGG®

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The world’s most documented probiotic strain

Lactobacillus rhamnosus, LGG® is the world’s most documented probiotic strain. It is used in food and dietary supplements and has been studied in hundreds of clinical studies, documenting both its efficacy and safety.

Chr. Hansen has produced and sold the proven LGG® strain, which is originally from Valio, since 1994. Through our strict processes, high quality controls and state-of-the-art sequencing this LGG® strain has remained entirely stable over these 25 years.


Only Chr. Hansen provides the real LGG®

Chr. Hansen uses state-of-the-art sequencing to generate a closed genome reference sequence of the LGG® probiotic strain. The genome results and sequences have been validated and endorsed by an independent third party. The Valio and Chr. Hansen production strain has remained stable and genomically identical over the last 25 years. It was observed in 2019 that the ATCC reference deposit of LGG (ATCC53103) was not genomically identical to the Chr. Hansen LGG® production strain or the published LGG sequence (deVos paper 2009). For this reason, the LGG® production strain from Chr. Hansen has been deposited at the DSMZ culture collection (DSM33156).


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The real LGG® from Chr. Hansen has had 100% genome stability for 25 years

The Chr. Hansen probiotic strain has remained stable and genomically identical over the last 25 years. We recently published a paper (Stage et al., 2019) describing and looking at the production process and showing how stable the LGG® is within the Chr. Hansen production environment.

 

The real LGG® by Chr. Hansen is the one used in over 75% of all clinical trial publications

Valio or Chr. Hansen supplied the LGG® strain to more than 75% of all clinical trial publications investigating Lactobacillus rhamnosus GG. This means that in less than 25% of the trial publications, the strain was supplied by another supplier or is unknown.

 

We’re constantly advancing production methods to ensure stability and quality

Chr. Hansen has always focused on the production process to ensure genomic stability and quality. Recently Chr. Hansen published results showing that the state-of-the-art production and quality control systems ensure that the Chr. Hansen LGG® probiotic strain is genomically identical throughout the production process and has remained exactly the same for the last 25 years (Stage et al., 2019).


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The results and sequences are provided and endorsed by an independent third party

Results from our genome and sequence analysis have been validated and endorsed by an independent third party. 
 
 
LGG® is a registered trademark of Chr. Hansen A/S.

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