One of the world's largest clinical studies on probiotics reinforces significant gastrointestinal benefits of the probiotic strain named BB-12®

One of the world's largest clinical studies on probiotics reinforces significant gastrointestinal benefits of the probiotic strain named BB-12®
Press ReleaseSep 25. 2015 10:39 GMT

Millions of people around the world suffer from a range of gastrointestinal symptoms. Worldwide, 12% of the population suffers from constipation[1]. In some regions, the prevalence of irritable bowel syndrome is as high as 23%.[2] One widely cited study concludes that normal bowel function is enjoyed by less than half of the population[3].

Results from one of the world’s largest clinical studies on probiotics now show that the probiotic strain named BB-12® can be part of the solution by improving bowel regularity.

The study, recently published in British Journal of Nutrition,was initiated by Chr. Hansen in 2011. It included more than 1200 subjects in France, UK and Germany; all healthy but experiencing low defecation frequency and abdominal discomfort. The study has produced the largest dataset ever published from a randomized, placebo-controlled study on the effect of probiotics on bowel function.

Results from the study show that the odds for having more regular bowel movements were significantly higher when consuming the BB-12® probiotic strain for four weeks, compared to the placebo group. This verifies results from previous studies, and shows a clinically relevant effect of the probiotic strain on bowel regularity.

Mikkel Jungersen, Scientific Advisor, Human Health & Nutrition, Chr. Hansen, says: “Once again, it is confirmed that the BB-12® probiotic strain can bring significant gastrointestinal benefits to those who experience digestive issues. What is truly unique about this study is its size, of more than 1200 subjects varying in age from 18 to 70, which has resulted in the largest dataset available on the effect of probiotics on bowel function”.

The best documented Bifidobacterium in the world

The BB-12® probiotic strain originates from Chr. Hansen’s culture collection, and has been used as an ingredient in food and dietary supplements since 1985. Over the last 30 years, more than 170 clinical studies have shown that this probiotic strain has a positive effect on the immune and gastrointestinal system. Today, it is consumed by hundreds of millions of people all over the world every day.

Mikkel Jungersen continues: “We are committed to delivering the best documented probiotics and the BB-12® probiotic strain is the best documented Bifidobacterium in the world. With these new results, it now truly stands out as a strong probiotics within bowel function.”

For more information on the study or on the probiotic strain named BB-12®,please do not hesitate to contact Mikkel Jungersen, Dkmkj@chr-hansen.com or visit the product website.



The Study

  • Eskesen et al. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12® on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomized, double-blind, placebo-controlled, parallel-group trial.

E-published ahead of print online September 21, 2015 in British Journal of Nutrition.

[1] A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation. Alimentary Pharmacology & Therapeutics; 2008.

[2] International Foundations for Functional Gastrointestinal Disorders (IFFGD), April 2014

[3] Hughes et al.: Defecation frequency and timing, and stool form in the general population: a prospective study. Gut 1992: 33, pp. 818-824


Chr. Hansen is a leading, global bioscience company that develops natural ingredient solutions for the food, nutritional, pharmaceutical and agricultural industries. We develop and produce cultures, enzymes, probiotics and natural colors for a rich variety of foods, confectionery, beverages, dietary supplements and even animal feed and plant protection. Our product innovation is based on more than 30,000 microbial strains – we like to refer to them as ‘good bacteria’. Our solutions enable food manufacturers to produce more with less – while also reducing the use of chemicals and other synthetic additives – which make our products highly relevant in today’s world. We have been delivering value to our partners – and, ultimately, end consumers worldwide – for over 140 years. We are proud that more than one billion people consume products containing our natural ingredients every day. Revenue in the 2017/18 financial year was EUR 1,097 million. Chr. Hansen was founded in 1874 and is listed on Nasdaq Copenhagen.

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