Probiotics

LGG®

Examples of published scientific articles, documenting the effect of LGG®:

Alander M, Satokari R, Korpela R, Saxelin M, Vilpponen-Salmela T, Mattila-Sandholm T, von Wright A. Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption. Applied and Environmental Microbiology 1999;65:351-4.

Armuzzi A, Cremonini F, Ojetti V, Bartolozzi F, Canducci F, Candelli M, Santarelli Cammarota G, De Lorenzo A, Pola P, Gasbarrini G, Gasbarrini A. Effect of Lactobacillus GG supplementation on antibiotic-associated gastointestinal side effects during Helicobacter pylori eradication therapy: a pilot study. Digestion 2001;63:1-7.

Armuzzi A, Cremonini F, Bartolozzi F, Canducci F, Candelli M, Ojetti V, Cammarota G, Anti M, De Lorenzo A, Pola P, Gasbarrini G, Gasbarrini A. The effect of oral administration of Lactobacillus GG on anitibiotic-associated gastointestinal side effects during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther 2001;15:163-9.

Arvola T, Laiho K, Torkkeli S, Mykkänen, Salminen S, Maunula L, Isolauri E. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Pediatrics 1999;104(5):e64.

Collins JK, Clune Y, Meaney K, o’Donoghue M, Klinder A, Roller M, Karlsson P, Bennett M, O’Riordan M, Dunne C, O’Sullivan G, Rafter J, Watzl B, Rechkemmer G, Pool-Zobel BL. 2005. The influence of synbiotic consumption on cancer risk biomarkers in previously resected colon cancer subjects. Abstracts / Journal of Biotechnology 118S1: S1-1189.

Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, Nista EC, Cammarota G, Gasbarrini G, Gasbarrini A. Effect of different probiotic preparations on anti-Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo controlled study. Am J Gastroenterol 2002;97:2744-9.

de Vrese M, Rautenberg P, Laue C, Koopmans M, Herremans T, Schrezenmeir J. Probiotic bacteria stimulate virus-specific neutralizing antibodies following a booster polio vaccination. Eur J Nutr 2005;44.406-13.

Goldin BR, Gorbach SL, Saxelin M, Barakat S, Gualtieri L, Salminen S. Survival of Lactobacillus species (strain GG) in human gastorintestinal tract. Dig Dis Sci 1992;37:121-8.

Guarino A, Canani, RB, Spagnuolo MI, Albano F, Di Benedetto L. Oral bacterial therapy reduces the duration of symptoms and of viral excretion in children with mild diarrhea. J Pediatr Gastroenterol Nutr 1997;25:516-9.

Guandalini S, Pasabene L, Zirki MA, Dias JA, Casali LG, Hoekstra H, Kolacek S, Massar K, Micetic-Turk D, Papadopoulou A, de Sousa JS, Sandhu B, Szajewska H, Weizman Z. Lactobacillus GG adminestred in oral rehydration solution to children with acute diarrhea: a multicenter european Trial. J Ped Gastroenterol Nutr 2000;30:54-60.

Hatakka K, Martio J, Korpela M, Herranen M, Poussa T, Laasanen T, Saxelin M, Vapaatalo H. Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis – a pilot study. Scand J Rheumatol 2003;32.211-5. 

Hatakka K, Savilahti E, Pönkä A, Meurman JH, Poussa T, Näse L. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 2001;322:1327-9.

Hilton E, Kolakowski P, Singer C, Smith M. Efficacy of Lactobacillus GG as a diarrheal prevention in travelers. J Travel Med 1997;4:41-3.

Isolauri, E., Arvola, T., Sutas, Y., Moilanen, E., Salminen, S. Probiotics in the management of atopic eczema. 2000. Clinical and Experimental Allergy, 30: 1604-1610.

Isolauri E, Joensuu J, Suomalainen H, Luomala M, Vesikari T. Improved immunogenicity of oral DxRRV reassortant rotavirus vaccine by Lactobacillus casei GG. Vaccine 1995;13:310-2.


Isolauri E, Kaila M, Mykkänen H, Ling WH, Salminen S. Oral bacteriotherapy for viral gastroenteritis. Dig Dis Sci 1994;39:2595-600.

Isolauri E, Juntunen M, Rautanen T, Sillanaukee P, Koivula T. A Human Lactobacillus strain (Lactobacillus Casei sp strain GG) promotes recovery from acute diarrhea in children. Pediatrics 1991;88:90-7.

Jung. Faseb J 1999;13:A872. (Abstract)

Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res 1992;32:141-4.

Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001;357:1076-9.

Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 2001;361:1869-71.

Kankaanpaa, P., Sutas, Y., Salminen, S., Isolauri, E. Results on clinical demonstraion of probiotics on children. Presented at Functional Food Research in Europe, Third Workshop, PROBDEMO, Finland, October 1-2, 1998.

Kirjavainen PV, Salminen SJ, Isolauri E. Probiotic bacteria in the management of atopic disease: underscoring the importance of vaibility. JPGN 2003;36:223-7.

Majamaa H, Isolauri E. probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol 1997;99.179-85.

Majamaa H, Isolauri E, Saxelin M, Vesikari T. Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr 1995;20:333-8.

Näse L, Hatakka K, Savilahti E, Saxelin M, Pönkä A, Poussa T, Korpela R, Meurman JH. Effect of long-term comsumption of a probiotic bacteria, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res 2001;35:412-420.

Oberhelman RA, Gilman RH, Sheen P, Taylor DN, Black RE, Cabrera L, Lescano AG, Meza R, Madico G. A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvean children. J Pediatr 1999;134:15-20.

Oksanen PJ, Salminen S, Saxelin M, Hämäläinen P, Ihantola-Vormisto A, Muurasniemi-Isoviita L, Nikkari S, Oksanen T, Pörsti I, Salminen E, Siitonen S, Stuckey H, Toppila A, Vapaatalo H. Prevention of travellers’ diarrhoea by Lactobacillus GG. Ann Med 1990;22:53-6.

Pant AR, Graham SM, Allen SJ, Harikul S, Sabchareon A, Cuevas Hart CA. Lactobacillus GG and acute diarrhea in young children in the Tropics. J Trop Pediatr 1996;42:162-5.

Pelto L, Isolauri E, Lilius EM, Nuutila J, Salminen S. Probiotic down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in helathy subjects. Clin Exp Allergy 1998;28:1474-9.
 
Pessi T, Sütas Y, Hurme M, Isolauri E. Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG. Clin Exp Allergy 2000;30:1804-8.

Pohjavuori E, Viljanen M, Korpela R, Kuitunen M, Tiitanen M, Vaarala O, Savilahti E. Lactobacillus GG effect in increasing IFN-gamma production in infants with cow’s milk allergy. J Allergy Clin Immunol 2004;114:131-6.

Rautanen T, Isolauri E, Salo E, Vesikari T. Management of acute diarrhoea with low osmolarity oral rehydration solutions and Lactobacillus strain GG. Arch Dis Child 1998;79:157-60.

Rautava S, Arvilommi H, Isolauri E. 2006. Specific probiotics in enhancing maturation of IgA responses in formula-fed infants. Pediatric Research 60(2): 222-225.

Rautava S, Kalliomäki M, Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol 2002;109:119-21.

Raza S, Graham SM, Allen SJ, Sultana S, Cuevas L, Hart CA. Lactobacillus GG promotes recovery from acute nonbloody diarrhea in Pakistan. Pediatr Infect Dis J 1995;14:107-11.

Saxelin M, Elo S, Salminen S, Vapaatalo H. Dose response colonisation of faeces after oral administration of Lactobacillus casei strain GG. Micr Ecol Health Dis 1991;4:209-14.

Schultz M, Cunningham-Rundles S, Lehn N, Falk W, Schölmerich J. Oral therapy with Lactobacillus GG alters the immune response towards bacteroides sp. Eur J Clin Invest 1999;29(suppl 1):78. (Abstract)

Shornikova A-V, Isolauri E, Burkanova L, Likovnikova S, Vesikari T. A trial in the Karelian Republic of oral rehydration and Lactobacillus GG for treatment of acute diarrhoea. Acta Paediatr 1997;86:460-5.

Siitonen S, Vapaatalo H, Salminen S, Gordin, Saxelin M, Wikberg R, Kirkkola A. Effect of Lactobacillus GG youhurt in prevention of antibiotic associated diarrhoea. Ann Med 1990;22:57-9. 

Szajewska H, Kotowska M, Mrukowicz JZ, Armanska M, Mikolajczyk W. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr 2001;138:361-5.

Vanderhoof JA, Whitney DB, Antonson DL, Hanner TL, Lupo JV, Young RJ. Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. J Pediatr 1999;135:564-8.

Vendt N, Grünberg H, Tuure T, Malminiemi O, Wuolijoki E, Tillmann V, Sepp E, Korpela R. Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: double-blind, randomized trial. J Hum Nutr Dietet 2006;19:51-8.

Viljanen M, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuute T, Kuitunen M. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy 2005;60:494-500.